服務承諾：
工作時間內(nèi)提供免費的技術(shù)咨詢和指導 。我公司的銷售工程師經(jīng)過專業(yè)培訓的，將為您提供滿意的產(chǎn)品和真誠的服務。
癸基-β-D-硫代吡喃葡萄糖苷號：98854-16-1
英文名稱：Decyl-β-D-1-thioglucopyranoside
其他名稱：十烷基-β-D-硫代吡喃葡萄糖苷
號：98854-16-1
C16H32O5S=336.49
級別：BR
含量：≥98%
性狀(以下信息僅供參考)：白色粉末。
用途：本品僅供科研，不得用于其它用途
保存：-20℃癸基-β-D-硫代吡喃葡萄糖苷號：98854-16-1儲存條件：
避光、干燥陰涼處封閉貯存,嚴禁與有毒、有害物品混放、混運。本品為非危險 產(chǎn)品可按一般化學品運輸,輕搬動輕放,防止日曬、雨淋！受熱、受潮、受光后易喪失活力,保存期短,因此貯存和運輸條件比較苛刻。
運輸：汽車運輸、EMS郵政快遞，申通快遞等， 款到上海3天內(nèi)發(fā)貨；
售后：如您對我們的產(chǎn)品服務及技術(shù)指標有特殊要求，請及時通知我方。
存儲：應貯存在干燥清潔避光的環(huán)境中，嚴禁與有毒物質(zhì)混放，以免污染（保質(zhì)期為兩年）。
癸基-β-D-硫代吡喃葡萄糖苷號：98854-16-1主要優(yōu)級純、分級純和化學純3種：
（1）優(yōu)級純（GR：Guaranteed reagent），又稱一級品或保證試劑，99.8%，這種試劑純度Z高，雜質(zhì)含量Z低，適合于重要精密的分析工作和科學研究工作，使用綠色瓶簽。
（2）分析純（AR），又稱二級試劑，純度很高，99.7%，略次于優(yōu)級純，適合于重要分析及一般研究工作，使用紅色瓶簽。
（3）化學純（CP），又稱三級試劑，≥ 99.5%，純度與分析純相差較大，適用于工礦、學校一般分析工作。使用藍色（深藍色）標簽。
（4）實驗試劑（LR：Laboratory reagent），又稱四級試劑。
Post-translational modifications : Phosphorylation of Ser-371 causes dimer dissociation. Phosphorylation by CK2 promotes interaction with APTX and APLF.
Sumoylated.
Similarity : Contains 2 BRCT domains.
Database links : UniProtKB/Swiss-Prot: P18887.2
XRCC-1是一種重要的DNA修復基因,在一系列內(nèi)外氧化劑(包括煙草成分)導致的DNA單鏈斷裂和堿基損傷修復中起到重要作用,是目前腫瘤研究的重要的蛋白。
英文名稱 Anti-XAF1/FBXO39
中文名稱 XIAP相關(guān)因子1凋亡抑制蛋白抗體
別 名 XIAP-associated factor 1; BIRC 4 binding protein; BIRC4-binding protein; XAF1; XAF1_MOUSE; XIAPAF1; BIRC 4 binding protein; BIRC4 binding protein; BIRC4BP; HSXIAPAF 1; HSXIAPAF1; XAF 1; XIAP associated factor 1; Fbxo39; RP24-450M24.4.
濃 度 1mg/1ml
規(guī) 格 0.1ml/100μg 0.2ml/200μg
抗體來源 Rabbit
克隆類型 polyclonal
交叉反應 Mouse, Rat
產(chǎn)品類型 一抗
研究領(lǐng)域 細胞生物 免疫學 細胞凋亡
蛋白分子量 predicted molecular weight: 31kDa
性 狀 Lyophilized or Liquid
免 疫 原 KLH conjugated synthetic peptide derived from mouse XAF1 C-terminus
亞 型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide
產(chǎn)品應用 WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500
（石蠟切片需做抗原修復）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is 癸基-β-D-硫代吡喃葡萄糖苷號：98854-16-1stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
產(chǎn)品介紹 XAF1 binds to XIAP, an inhibitor of caspases-3, -7, and -9, and triggers its relocation from the cytosol to the nucleus. Overexpression of XAF1 results in the neutralization of XIAP's ability to inhibit cell death. XAF1 is normally expressed in all adult and fetal tissues but is present at very low levels in a variety of cancer cell lines. In contrast, XIAP levels have been shown to be high in a majority of cell lines. Low XAF1 and high basal expression of XIAP may therefore play a critical role in maintaining survival of cancer cell lines.
Function : Seems to function as a negative regulator of members of the IAP (inhibitor of apoptosis protein) family. Inhibits anti-caspase activity of BIRC4. Induces cleavage and inactivation of BIRC4 independent of caspase activation. Mediates TNF-alpha-induced apoptosis and is involved in apoptosis in trophoblast cells. May inhibit BIRC4 indirectly by activating the mitochondrial apoptosis pathway. After translocation to mitochondra, promotes translocation of BAX to mitochondria and cytochrome c release from mitochondria. Seems to promote the redistribution of BIRC4 from the cytoplasm to the nucleus, probably independent of BIRC4 inactivation which seems to occur in the cytoplasm. The BIRC4-XAF1 complex mediates down-regulation of BIRC5/survivin; the process requires the E3 ligase activity of BIRC4. Seems to be involved in cellular sensitivity to the proapoptotic actions of TRAIL. May be a tumor suppressor by mediating apoptosis resistance of cancer cells (By similarity).
Subunit : Interacts with BIRC1, BIRC2, BIRC3, BIRC4, BIRC7 and BIRC8. Part of an complex consisting of BIRC4, XAF1 and BIRC5; the complex formation requires IFN-beta stimulation (By similarity).
Subcellular Location : Cytoplasm (By similarity). Nucleus (By similarity). Mitochondrion (By similarity).
Similarity : Contains 1 TRAF-type zinc finger.
Database links : UniProtKB/Swiss-Prot: Q5NBU8.3
XAF1是一個新近發(fā)現(xiàn)的通過與XIAP直接結(jié)合拮抗其抗凋亡作用的蛋白因子。XAF1是一個新的腫瘤抑制基因，XAF1在多種腫瘤細胞和組織中存在低表達或表達缺失。其過度表達可誘導凋亡，抑制腫瘤生長。
英文名稱 Anti-XBP-1
中文名稱 細胞核轉(zhuǎn)錄因子X盒結(jié)合蛋白抗體
別 名 X box-binding protein-1; XBP-1; XBP2; Tax responsive element binding protein 5; TREB5; X box binding protein 2; XBP 1; XBP2.
濃 度 1mg/1ml
規(guī) 格 0.1ml/100μg 0.2ml/200μg
抗體來源 Rabbit
克隆類型 polyclonal
交叉反應 Human, Mouse, Rat, Chicken, Pig, Cow
產(chǎn)品類型 一抗
研究領(lǐng)域 轉(zhuǎn)錄調(diào)節(jié)因子 表觀遺傳學
蛋白分子量 predicted molecular weight: 29kDa
性 狀 Lyophilized or Liquid
